Our Purpose
Our Laboratory Research Unit aims to advance basic and translational knowledge of the natural history of infectious diseases, pathogen-host interactions, and their correlation with therapeutic responses. We take a multidisciplinary approach to contribute to the development of control strategies, diagnostics, and treatments relevant to public health events in Colombia and the region.
RESEARCH LABORATORIES
Our research laboratories are designed and equipped to meet the specific needs of various pathogens and disciplinary approaches, including immunology, molecular biology, cellular biology, biochemistry, and pharmacology.
The Molecular Biology and Biochemistry laboratory specializes in implementing high-throughput technologies such as proteomics, metabolomics, and transcriptomics of microorganisms and their hosts. We conduct functional analyses of genes, metabolic pathways, and signaling pathways to cover a broad spectrum of molecular research. This ranges from discovering candidate molecules for therapeutic interventions, diagnostics, or biomarkers to validating their functionality.
Our Immunology and Cell Biology laboratory focuses on understanding the functional aspects and phenotypic and genotypic characteristics of the host immune response to pathogens and/or drugs. We aim to identify intervention strategies and modulate the immune response for improved clinical outcomes in infectious diseases.
The Microbiology laboratory aims to comprehend pathogenicity mechanisms, transmission dynamics (genomic epidemiology), and drug resistance markers through phenotypic and genotypic characterizations of various microorganisms. We employ techniques such as whole-genome sequencing, pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), and quantitative real-time PCR (qRT-PCR), among others.
The BSL-2+ laboratory is a secure workspace for handling microorganisms present in the community that are associated with moderate or severe human diseases. Compared to a conventional BSL-2 laboratory, this type of laboratory includes enhanced biosafety measures, such as the mandatory use of biosafety cabinets and personal protective equipment. Its design enables the study of moderately hazardous infectious agents while protecting personnel and the environment.
This laboratory uses advanced molecular biology tools to quickly and accurately detect the genetic material of viruses, bacteria, and other pathogens. Techniques such as PCR (polymerase chain reaction) make it possible to identify infections in their earliest stages. This is crucial for diagnosing infectious and tropical diseases, conducting epidemiological surveillance, and supporting research studies.
This laboratory specializes in detecting leishmaniasis, a tropical disease spread through the bites of infected sandflies. The laboratory performs diagnostic tests on clinical samples to confirm the presence of the Leishmania parasite. These tests combine traditional methods, such as microscopic examination, with molecular techniques. The laboratory's work supports the timely treatment of patients and research into this neglected disease that affects vulnerable communities.
SUPPORT LABORATORIES
Our Biobank offers comprehensive support to our research teams and processes, both internally and in collaboration with other institutions. It focuses on managing, preserving, and safeguarding biological and human samples, along with their associated clinical and/or research information. We adhere to rigorous quality standards and comply with national and international ethical and legal regulations. Additionally, we provide specialized services for storage in cryopreservation facilities and processing samples from research projects.
Our Materials laboratory provides essential support to research equipment and processes, as well as diagnostic services, by preparing and sterilizing materials, solutions, culture media, and disposing of biological waste. All procedures are conducted in accordance with national legal requirements and the highest quality standards.
